Browsing by Author "Santoso, Broto"
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3D-MOLECULAR SCREENING OF DIKETOPIPERAZINE DERIVATES ON Staphylococcus aureus DEHYDROSQUALENE SYNTHASE USING VINA
Santoso, Broto (Farmasi UMS, 2012-06)Dehydrosqualene synthase enzyme has been used as protein target model for exploring docking simulation of pyrazoline analogues. One of diketopiperazine derivates that have similar structure to pyrazoline has antibacterial ... -
Analisis Profil Metabolit Sekunder Ekstrak Lempuyang Emprit dengan Kromatografi Gas-Spekstroskopi Massa
Hanwar, Dedi; Suhendi, Andi; Trisharyanti, Ika; Santoso, Broto; Safitri, Meisa; Haryoto (Universitas Muhammadiyah Surakarta, 2015-01-24)Lempuyang emprit (Zingiber amaricans Bl) is one of the plants species that contain secondary metabolites that are important in diseases treatment. This study was conducted to determine the secondary metabolites contained ... -
Antibacterial Activity of 3,6-Bis [(4-Hydroxy-3,5-Dimethylphenyl)Methylidene] Piperazine-2,5-Dione against Staphylococcus aureus, Escherica coli and Bacillus subtilis
Santoso, Broto; Shani, Yasinta M; Haryoto; Ulfa, Amelia M (Universitas Muhammadiyah Surakarta, 2012-11)Curcumin has antibacterial activity. Modification of curcumin to obtain a more potent compound, stable, safe, effective, and has a better activity has been widely applied. Some of them are derived compounds of pentagamavunon ... -
Comparison of Free Docking Tools
Santoso, Broto (Universitas Muhammadiyah Surakarta, 2014-06)Database of natural medicinal compounds, primarily derived from plants are widely available, distributed and can be accessed for free via the Internet. The protein database that is responsible for a particular disease ... -
DOCKING ANALOG KURKUMIN TURUNAN PIPERAZINDION DENGAN TUBULIN (1TUB) RANTAI Beta MENGGUNAKAN VINA DAN AUTODOCK
Santoso, Broto (Farmasi UMS, 2011-06)Program Autodock mampu memprediksi energi bebas dan konformasi ikatan antara fleksibel ligan dan makromolekul target yang telah diketahui. Senyawa turunan dan analog kurkumin adalah ligan yang telah banyak dihasilkan dan ... -
EXPLORING 3D MOLECULAR STUDIES OF DIKETOPIPERAZINE ANALOGUES ON Staphylococcus aureus DEHYDROSQUALENE SYNTHASE USING GLIDE-XP
Santoso, Broto (Farmasi UMS, 2012-12)There is a strong correlation between 3D molecular docking result with dehydrosqualene synthase protein and antibacterial activity against Staphylococcus aureus (S. aureus) of the pyrazoline analogues. The enzyme has been ... -
Identifikasi Agen Antidiabetes Melalui Jalur Penghambatan Aldose Reductase Menggunakan Pyrxdengan Empat Algoritma Molecular Docking
Salim Maulana, Agus; Wulansari, Kiki; Anwar Zhelsiana, Devy; Sri Sulasmi, Wiwin; Santoso, Broto (STIKES Muhammadiyah Pekajangan, 2016-08-27)Aldosereductaseisaldo-ketoreductaseenzyme that convert glucoseto sorbitol and fructosebypolyolpathway. Accumulation of sorbitol andoxidative stress dueto changes in the ratio of NADPH/NADP+ and NADH/NAD+ cause some ... -
Kajian Docking Molekular Pada Binding Site Pocket Dari Flavopiridol Dalam Menghambat Glikogen Fosforilase Menggunakan Pyrx-Autodock-Vina
Farid Yoga Pratama, Miftah; Rosyad Abidi, Subhan; Arum Firdaus, Khisma; Fitri Aulia, Alif; Santoso, Broto (STIKES Muhammadiyah Pekajangan, 2016-08-27)nhibition of the enzyme glycogen phosphorylase which break down glycogen into glucose 1- phosphate (glycogenolysis) is a target in the treatment of type 2 diabetes milletus. Interaction mechanism between glycogen phosphorylase ... -
Molecular Docking of Antioxidant Compounds: Groups of Flavonoid and Phenolic from Eight Indonesian Medicinal Plants
Nurmalitasari, Desy; Hikmawati, Agni; Hidayati, Laily; Santoso, Broto (Universitas Muhammadiyah Surakarta, 2014-06)Indonesia is a well-known country with a variety of resources vegetables and fruits. Most of them are used as a prospectus cure for cancer within antioxidant mechanisms. Some parts of these plants are eucalyptus leaves, ... -
PEMISAHAN SENYAWA-SENYAWA YANG BERSIFAT ANTIMALARIA DARI EKSTRAK METANOL KULIT KAYU MIMBA ( Azadirachta Indica JUSS)
Djumadi; Santoso, Broto (LPPM UMS, 2008-09)Telah dilakukan penelitian untuk mengamati aktivitas antiplasmodium dari ekstrak metanol kulit kayu mimba (Azadirachta indica). Fraksi yang diamati adalah fraksi nonpolar, semipolar dan polar yang diperoleh dengan ... -
Pemodelan In Silico Inhibitor Gsk-3β (CHIR99021, CHIR98014, AZD1080, TWS11) Dan Turunan Zerumbon Terhadap Protein 4PTG Melalui Perangkat Lunak PYR
Roro Shafira Meisy Sudarsono, Raden; Dwi Puspita Sari, Hana; Beny Santosa, Agung; Ayu Resti Lailya Anggraini, Dyah; Santoso, Broto (STIKES Muhammadiyah Pekajangan, 2016-08-27)Glycogen synthase kinase-3 (GSK-3) is a serine / threonine kinase whose activity is related to various diseases such as diabetes, cancer, Alzheimer's, and stroke. In silico method is one of the choice to study and look for ... -
PENETAPAN KADAR ASAM ASETILSALISILAT DALAM SEDIAAN OBAT MEMANFAATKAN SINAR REFLEKTAN TERUKUR DARI BERCAK YANG DIHASILKAN DENGAN TLC SCANNER
Suhendi, Andi; Santoso, Broto (LPPM-UMS, 2009)Acetosal is consumed by people as analgesic and anti-pyretic so high quality of the product is required. Hydrolysis result of this compound is acetyl salicylic acid which is detected by forming complex of color compound ... -
Pengembangan dan Validasi Penetapan Kadar Tablet Besi (II) Sulfat dengan Kalium Permanganat-Salisilat secara Spektrofotometri Visibel
Santoso, Broto; Da’i, Muhammad; Setiyowati (Universitas Muhammadiyah Surakarta, 2009-12)Serimetri merupakan prosedur resmi Farmakope Indonesia Edisi IV untuk penetapan kadar tablet besi (II) sulfat. Metode ini memerlukan pembiayaan yang tidak sedikit dan ion besi (II) sendiri dapat teroksidasi menjadi ion ... -
Prediksi 3d-Molekular Aktivitas Turunan Senyawa Polihidroksi Zerumbon Terhadap Glikogen Sintase Kinase-3 Beta (GSK-3B) Menggunakan Dock6
Santoso, Broto; Hanwar, Dedi; Suhendi, Andi (LPPM Universitas Muhammadiyah Semarang, 2016-02)Insulin resistance causes 90% of type 2 diabetes mellitus (DM) cases and this is due to an increase in the activity of glycogen synthase kinase-3 (GSK-3). Dephosphorylation and activation of glycogen synthase ... -
Purple Sweet Potato Leaves: Antioxidant Activity by DPPH, CUPRAC, FTC, TBA methods and Molecular Docking Profile using Dock6
Fitri, Hidayah Annisa; Rahayu, Titis; Santoso, Broto; Suhendi, Andi (Universitas Muhammadiyah Surakarta, 2014-06)Purple sweet potato leaves is one of crop plants that has natural antioxidants potency because it contains phenolic and flavonoid compounds. The aim of this experiment was to determine the effect of leaf drying method ... -
Sensor Kolorimetrik Berbasis Agregasi Nanopartikel Emas dan Polimer Responsif pH Poli(Asam Akrilat)
Wikantyasning, Erindyah R; Rizqiyana, Fika; Santoso, Broto; Suprapto (Universitas Muhammadiyah Surakarta, 2015-01-24)The synthesis and pH-sensitive behavior of poly(acrylic acid) (PAA) and gold nanoparticles (AuNPs) are presented. Gold nanoparticles was synthesized by Turkevich method and analyzed by TEM and UV-Vis spectrophotometer ... -
Sintesis Senyawa (2E)-3-Fenilprop-2-Enoil 3,4,5- Trihidroksibenzoat Dengan Menggunakan Microwave
Kuswandi, M.; Kusumaningtyas, Erwinda; Santoso, Broto (STIKES Muhammadiyah Pekajangan, 2016-08-27)A drug compounds can be obtained through synthesis by modifying the structure of potential. Gallic acid and cinnamaldehyde alleged to have potent antioxidant activity. If two compounds are combined is expected to form a ... -
Sintesis Senyawa 4 Formil 2 Metoksifenil 3,4,5 Trihidroksibenzoat Melalui Pemanasan
Kuswandi, M.; Krismiyati, Dwi; Santoso, Broto (STIKES Muhammadiyah Pekajangan, 2016-08-27)Gallic acid and vanillin are medicines that have anticancer potency of synergism, if both of them were reacted in order to get new compound and to have a better activity. Its docking study expressed a better value than ... -
SINTESIS SENYAWA ANALOG KURKUMIN 3,6-BIS-(4’-HIDROKSI-3’,5’-DIMETILBENZILIDIN)-PIPERAZIN-2’,5’-DION DENGAN KATALIS HCl
Wahyuni, Retno Hari; Da'i, Muhammad; Santoso, Broto (Farmasi UMS, 2009-12)Kurkumin merupakan pemberi warna pada rhizoma tanaman Curcuma longa L. Selain digunakan sebagai pewarna alami, kurkumin juga telah diteliti memiliki aktivitas biologis sebagai antiradikal dan antikanker. Kestabilan kurkumin ... -
Validasi Metode Penetapan Kadar Tablet Ferro-Sulfat Memanfaatkan Sinar Reflektan Tlc Scanner
Santoso, Broto (Universitas Muhammadiyah Surakarta, 2009-12)Ion Ferro diketahui dapat dioksidasi menjadi ion Ferri yang dapat bereaksi secara kuantitatif dengan asam salisilat membentuk senyawa kompleks berwarna ungu. Tablet Ferro-Sulfat mengandung ion Ferro sehingga kadar zat aktif ...